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1000 Titel
  • Trait correlated expression combined with expression QTL analysis reveals biological pathways and candidate genes affecting water holding capacity of muscle
1000 Autor/in
  1. Ponsuksili, Siriluck |
  2. Jonas, Elisabeth |
  3. Murani, Eduard |
  4. Phatsara, Chirawath |
  5. Srikanchai, Tiranun |
  6. Walz, Christina |
  7. Schwerin, Manfred |
  8. Schellander, Karl |
  9. Wimmers, Klaus |
1000 Erscheinungsjahr 2008
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2008-07-31
1000 Erschienen in
1000 Quellenangabe
  • 9: 367
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2008
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1186/1471-2164-9-367 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529315/ |
1000 Ergänzendes Material
  • http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-367#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Leakage of water and ions and soluble pr oteins from muscle cells occurs during prolonged exercise due to ischemia causing muscle damage. Also post mortem anoxia during conversion of muscle to meat is marked by loss of water and soluble components from the muscle cell. There is considerable variation in the water holding capacity of meat affecting economy of meat production. Water holding capa city depends on numerous geneti c and environmental factors relevant to structural and biochemical muscle fibre properties a well as ante and post slaughter metabolic processes. RESULTS: Expression microarray analysis of M. longissimus dorsi RNAs of 74 F2 animals of a resource population showed 1,279 transcripts with trait co rrelated expression to water holding capacity. Negatively correlated transcript s were enriched in functional categories an d pathways like extracellular matrix receptor interaction an d calcium signalling. Transcripts with positive correlation dominantly represented biochemical processes including oxid ative phosphorylation, mitochondrial pathways, as well as transporter a ctivity. A linkage analysis of abundance of trait correlated transcripts revealed 897 expression QTL (eQTL) with 104 eQTL coinciding with QTL regions for water holding capacity; 96 transcripts had trans acting and 8 had cis acting regulation. CONCLUSION: The complex relationships betw een biological processes taking place in live skeletal muscle and meat quality are driven on the one hand by the energy reserves and their utilisation in the muscle and on the other hand by the muscle structure itself and calcium signalling. Holistic expression profiling was integrated with QTL an alysis for the trait of interest and for gene expression levels for crea tion of a priority list of genes out of the orchestra of genes of biological networks relevant to the liability to develo p elevated drip loss.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/Sm9uYXMsIEVsaXNhYmV0aA==|https://frl.publisso.de/adhoc/creator/TXVyYW5pLCBFZHVhcmQ=|https://frl.publisso.de/adhoc/creator/UGhhdHNhcmEsIENoaXJhd2F0aA==|https://frl.publisso.de/adhoc/creator/U3Jpa2FuY2hhaSwgVGlyYW51bg==|https://frl.publisso.de/adhoc/creator/V2FseiwgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=|https://frl.publisso.de/adhoc/creator/U2NoZWxsYW5kZXIsIEthcmw=|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. German Research Foundation (Deutsche Forschungs-gemeinschaft, DFG; Forschergruppe 'DRIP' |
1000 Fördernummer
  1. FOR 753
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (Deutsche Forschungs-gemeinschaft, DFG; Forschergruppe 'DRIP' |
    1000 Förderprogramm -
    1000 Fördernummer FOR 753
1000 Objektart article
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1000 @id frl:6402758.rdf
1000 Erstellt am 2017-06-02T11:11:49.131+0200
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1000 Zuletzt bearbeitet Wed Jun 27 11:26:23 CEST 2018
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  1. oai:frl.publisso.de:frl:6402758 |
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