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1000 Titel
  • The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
1000 Autor/in
  1. Delahaye-Sourdeix, Manon |
  2. Oliver, Javier |
  3. Timofeeva, Maria N |
  4. Gaborieau, Valérie |
  5. Johansson, Mattias |
  6. Chabrier, Amélie |
  7. Wozniak, Magdalena B |
  8. Brenner, Darren R |
  9. Vallée, Maxime P |
  10. Anantharaman, Devasena |
  11. Lagiou, Pagona |
  12. Holcátová, Ivana |
  13. Richiardi, Lorenzo |
  14. Kjaerheim, Kristina |
  15. Agudo, Antonio |
  16. Castellsagué, Xavier |
  17. Macfarlane, Tatiana V |
  18. Barzan, Luigi |
  19. Canova, Cristina |
  20. Thakker, Nalin S |
  21. Conway, David I |
  22. Znaor, Ariana |
  23. Healy, Claire M |
  24. Zaridze, David |
  25. Szeszenia-Dabrowska, Neonilia |
  26. Lissowska, Jolanta |
  27. Fabianova, Eleonora |
  28. Mates, Ioan Nicolae |
  29. Bencko, Vladimir |
  30. Foretova, Lenka |
  31. Janout, Vladimir |
  32. Curado, Maria Paula |
  33. Koifman, Sergio |
  34. Menezes, Ana |
  35. Wünsch-Filho, Victor |
  36. Eluf-Neto, José |
  37. Boffetta, Paolo |
  38. Fernández Garrote, Leticia |
  39. Serraino, Diego |
  40. Lener, Marcin |
  41. Jaworowska, Ewa |
  42. Lubiński, Jan |
  43. Boccia, Stefania |
  44. Rajkumar, Thangarajan |
  45. Samant, Tanuja A |
  46. Mahimkar, Manoj B |
  47. Matsuo, Keitaro |
  48. Franceschi, Silvia |
  49. Byrnes, Graham |
  50. Brennan, Paul |
  51. McKay, James D |
  52. Ahrens, Wolfgang |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-20-03
1000 Erschienen in
1000 Quellenangabe
  • 10(3): e0117639
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0117639 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368781/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117639#sec022 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04–1.15, p = 6x10(−4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(−3)) and LUSC (p = 9x10(−4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(−48) and p = 3x10(−29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
1000 Sacherschließung
lokal RNA sequencing
lokal lung and intrathoracic tumors
lokal DNA methylation
lokal genetic predisposition
lokal squamous cell lung carcinoma
lokal squamous cell carcinomas
lokal gene expression
lokal genetic loci
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Förderer
  1. US National Institutes of Health |
  2. National Institute of Dental and Craniofacial Research |
1000 Fördernummer
  1. R01 CA092039 05/05S1
  2. 1R03DE020116
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer US National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer R01 CA092039 05/05S1
  2. 1000 joinedFunding-child
    1000 Förderer National Institute of Dental and Craniofacial Research |
    1000 Förderprogramm -
    1000 Fördernummer 1R03DE020116
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405163.rdf
1000 Erstellt am 2017-10-25T10:19:15.983+0200
1000 Erstellt von 122
1000 beschreibt frl:6405163
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 27 10:20:31 CEST 2018
1000 Objekt bearb. Wed Jun 27 10:20:31 CEST 2018
1000 Vgl. frl:6405163
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405163 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von